Global Osteosarcoma News

From the National Cancer Institute

• In five cancer types, prevention and screening have been major contributors to saving lives
  Over the past 45 years, the majority of deaths averted from breast, cervical, colorectal, lung, and prostate cancer were due to prevention and screening, rather than treatment advances, NCI researchers have found.
• Researchers uncover new role of mutant RAS proteins in some of the deadliest cancers
  A new study led by NCI researchers shows that mutant RAS proteins help release a nuclear protein from a complex transported from the nucleus to the cytoplasm, kicking off a series of events that lead to the breakdown of a tumor suppressor protein.
• NIH-funded scientists uncover clues to precancer and tumor biology
  New studies released by NCI’s Human Tumor Atlas Network explore the role of the tumor microenvironment and the immune system in promoting the spread of cancer and its resistance to treatment. The studies appear across several Nature journals.
• NIH clinical trial will test precision medicine treatments for myeloid cancers
  NCI has launched myeloMATCH, a precision medicine treatment trial that will test treatment combinations targeting specific genetic changes in people with acute myeloid leukemia and myelodysplastic syndromes.
• New cancer diagnoses did not rebound as expected following pandemic
  While new cancer diagnoses largely returned to pre-pandemic levels in 2021, they don’t account for the missed diagnoses in early 2020 that resulted from disruptions in cancer screening and other medical care.
• Immunotherapy after surgery helps people with high-risk bladder cancer live cancer-free longer
  An NCI trial shows that giving patients pembrolizumab after surgery for high-risk muscle invasive bladder cancer doubles the median length of time that they remain cancer free, compared with observation alone after surgery.
• NIH study links neighborhood environment to prostate cancer risk in men with West African genetic ancestry
  A new study suggests, for men with West African genetic ancestry, living in a disadvantaged neighborhood was associated with a higher risk of prostate cancer. The researchers posit that chronic stress—such as from racial profiling, housing discrimination, and exposure to violence—may be a possible driver.
• Immunotherapy approach shows potential in some people with metastatic solid tumors
  A new cellular immunotherapy approach shrank tumors in 3 of 7 patients with metastatic colon cancer, in a small NCI clinical trial. Normal white blood cells from each patient were genetically engineered to produce receptors that recognize and attack their specific cancer cells.